Professor Grimmond is internationally recognised as a leader in cancer genomics, a pioneer of transcriptomics, and a committed advocate to genome-directed medicine. Over the last 25 years he has led a broad research program which uses transcriptome dynamics and genome content to uncover the underlying genetics controlling malignancies, developmental defects and pluripotency. Since 2009, Professor Grimmond has led Australia’s contribution to the International Cancer Genome Consortium and resolved the root causes, driving mutations and potential therapeutic targets present in some of our most challenging malignancies including pancreatic, melanoma, ovarian, neuroendocrine, and oesophageal cancers.