Professor Nicholls’ research career spans the translational spectrum from fundamental laboratory discoveries, study of patients and clinical trials that have had a major impact on the clinical practice of cardiology. He has an internationally regarded expert in the fields of lipoproteins, atherosclerosis, plaque imaging and cardiology clinical trials. His major contributions include elucidating the factors influencing the functionality of high density lipoproteins, understanding the factors influencing plaque progression and regression and the leadership of clinical trials of novel therapies. His work has a major impact on international treatment guidelines for the management of lipid disorders and in the evaluation of novel therapies.